acute myeloid leukemia | Scholarship for Nigerians and Africans

3 Postdoctoral Positions in Normal and Malignant Stem Cell Research, Denmark

We are interested in the underlying mechanisms governing the properties of normal and malignant stem cells. Our main focus is, very broadly, how the control of gene expression contributes to the biology of normal hematopoietic stem cells and how this control is altered in acute myeloid leukemia.

Research in the group involves the use of a number of experimental systems including human patient samples as well as genetically modified mouse models. We have strong expertise in multicolor flow cytometry and use a number of genomic techniques – such as ChIP-seq to assess transcription factor binding and epigenetic configurations as well as micro array and sequencing-based (RNA-seq) gene expression profiling. Importantly, the interpretation of these data is supported by a number of “in-group” bioinformaticians as well as extensive collaborations with the neighboring Bio informatics Centre. Thus, the successful candidates will join a dynamic research environment with access to all modern facilities.

Scholarship Application Deadline:
June 1, 2011.

Further Scholarship Information and Application

PhD Student for Molecular Carcinogenesis, Netherlands: Biomedical Sciences

Recurring chromosomal abnormalities have been identified in a variety of cancers, but are most frequently associated with haematological malignancies such as acute myeloid leukemia (AML). These cytogenetic changes often cause gene fusions leading to expression of chimeric oncofusion proteins. In this project you will focus on unravelling the role of these oncofusion proteins in carcinogenesis. Your aim will be to identify the binding regions, the transcriptional consequences and epigenetic features associated with oncofusion protein expression. You will use next-generation sequencing to identify oncofusion protein target sites, which then will be further characterized, structurally as well as functionally, in relation to the aetiology of acute myeloid leukemia.

You should have:
• an MSc degree in Biomedical Sciences/Biology/Molecular Life Sciences/Bioinformatics;
• experience in Molecular and Cell Biology and/or Bioinformatics;
• a strong affinity for fundamental research related to human disease;
• a well-structured working style;
• well-developed social and communication skills.

Conditions of employment
Employment: 1,0 fte
Maximum salary per month, based on a fulltime employment: € 2,612 gross/month
The starting salary is € 2,042 per month and will increase to € 2,612 per month in the fourth year. PhD scale.
Duration of the contract: 4 years
Scholarship Application Deadline: 14 January 2011
Further Scholarship Information and Application