The peptide under initial investigation is hemokinin (HK1), a decapeptide member of the tachykinin family of peptides identified in the mouse with the sequence SRTRQFYGLM-NH2. The equivalent human peptides are termed “endokinins” and differ in a number of subtle ways from hemokinin. The biology of the peptides is not well understood, although it is believed they play an important part in the regulation of the circulatory system. The approach will be twofold involving both organic synthesis and molecular biology. (i) Synthesis of hemokinin analogues will be carried out in proof of concept studies using a novel general ligation strategy developed in the Harwood group that does away with the need for a cysteine residue at the N-terminus, and permits Fmoc protection for generating the C–terminus thioester. (ii) Binding to mouse tachykinin receptors will be studind using radiolabelled HK1 analogues to establish structure activity profiles and identify agonists/antagonists. The analogues will also be studied for their role in platelet function – specifically secretion, integrin affinity modulation and aggregation, and through studying the cell signalling generated by these and the cell lines, develop an understanding of which specific receptors are of importance for the responses observed. These studies mesh with current expertise and interests with the Bicknell and Gibbins groups and might be further extended to endokinin analogues. Applications forms are available from Mrs. Judy Butler, Postgraduate Secretary, Chemistry Department, University of Reading, Whiteknights, Reading, Berks, RG6 6AD, Telephone Number: 01183786591 or by email j.m.butler@reading.ac.uk. Application Deadline October2010 Read more: http://scholarship-positions.com/phd-studentshipsynthetic-and-structure-activity-studies-on-hemokinin-and-analoguesuniversity-of-reading-uk/2010/08/10/?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+ScholarshipPositions+%28International+Scholarships+and+Financial+Aid+Positions%29&utm_content=Yahoo%21+Mail#ixzz0x8foh5VQ
PhD Studentship, Synthetic and Structure-Activity Studies on Hemokinin and Analogues, University of Reading, UK
Postdoctoral Researcher in Non-Equilibrium Statistical Mechanics, UK
We offer a 3-year post-doctoral position in Non-Equilibrium Statistical Mechanics within the interdisciplinary group led by Dr. Lucarini. The position is funded through the EU-ERC project NAMASTE.
The research will focus on the analysis of the statistical mechanical properties of the climate systems using theoretical tools and models of various degrees of complexity. Attention will be devoted to the rigorous analysis of the response of the system to perturbations. The impact of stochastic forcings will also be addressed.
Informal contact details
Contact role: Principal Investigator
Contact name: Valerio Lucarini
Contact phone: +44 (0)118 3785573
Contact email: v.lucarini@reading.ac.uk
We invite you to apply online for this vacancy by clicking the link at the bottom of this page.
Alternatively, if you wish to apply using a hardcopy form please email recruitment@reading.ac.uk or contact Human Resources, University of Reading, Whiteknights, PO Box 217, Reading RG6 6AH or Telephone +44(0)118 378 6771 (voicemail).
Application closing date 03/09/2010
