The post-doc will be involved in the micromechanical modeling at the polycrystal scale. The aim is to integrate into the polycrystal model slip-system resistances inferred from experimental data, ab initio calculations, and Dislocation Dynamics (DDD). The used polycrystal model will be based on mean-field homogenization methods (self-consistent scheme associated with the “Second-Order” linearization procedure of Ponte Castañeda), although numerical computations from full-field methods could be also performed if necessary. Micromechanical modeling of such material is a challenging task since all mineral phases comprising the upper mantle exhibit an extreme viscoplastic anisotropy at the grain scale, with three or less known independent slip systems. There are many effects to be investigated, important for
both geophysical and material sciences issues, e.g.: strain partition and texture development in multiphase minerals, the rheology of partially melted polycrystals, the introduction of diffusion based mechanisms (such as dislocation climb), etc.
Fellowship Application Deadline: January 2011
Further Fellowship Information and Application
Postdoctoral for project MANTLE RHEOLOGY, France: Micromechanical modeling
PhD Student for Molecular Carcinogenesis, Netherlands: Biomedical Sciences
Recurring chromosomal abnormalities have been identified in a variety of cancers, but are most frequently associated with haematological malignancies such as acute myeloid leukemia (AML). These cytogenetic changes often cause gene fusions leading to expression of chimeric oncofusion proteins. In this project you will focus on unravelling the role of these oncofusion proteins in carcinogenesis. Your aim will be to identify the binding regions, the transcriptional consequences and epigenetic features associated with oncofusion protein expression. You will use next-generation sequencing to identify oncofusion protein target sites, which then will be further characterized, structurally as well as functionally, in relation to the aetiology of acute myeloid leukemia.
Requirements
You should have:
• an MSc degree in Biomedical Sciences/Biology/Molecular Life Sciences/Bioinformatics;
• experience in Molecular and Cell Biology and/or Bioinformatics;
• a strong affinity for fundamental research related to human disease;
• a well-structured working style;
• well-developed social and communication skills.
Conditions of employment
Employment: 1,0 fte
Maximum salary per month, based on a fulltime employment: € 2,612 gross/month
The starting salary is € 2,042 per month and will increase to € 2,612 per month in the fourth year. PhD scale.
Duration of the contract: 4 years
Scholarship Application Deadline: 14 January 2011
Further Scholarship Information and Application
