Our vision is to assess the structure, supramolecular organization and dynamics of membrane transport proteins by transmission electron microscopy (TEM), atomic force microscopy (AFM) and X-ray crystallography (XRC). To this end, we clone, over-express, purify and crystallize transport proteins in 2- (2D) and 3-dimensions (3D). 2D crystals are analyzed by TEM/electron crystallography and AFM, while 3D crystals by XRC. Tasks of the successful candidates will involve cloning, over-expression and purification of pro- and eukaryotic membrane transport proteins for functional and structural studies. Our work is part of the National Centre of Competence in Research (NCCR) TransCure – From transport physiology to identification of therapeutic targets.
Required qualifications The Postdoc / Ph.D. candidate should have a Ph.D. / Master degree in molecular biology or biochemistry. Experience with the over-expression in bacteria and yeast, and with the biochemistry of membrane proteins is compulsory. Experience with transmission electron microscopy, atomic force microscopy or X-ray crystallography would be an advantage.
Scholarship Application Deadline: January 2011
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