Biology | Scholarship for Nigerians and Africans - Part 39

Postdoctoral Scientist in Cystic Fibrosis and Calcium Signaling Research,University of Bretagne Occidentale, France

/ August 22, 2010 Leave a Comment

: A 12-month post-doctoral position in the area of ion channel physiology and calcium signaling funded by the Conseil Général du Finistère is available for January 2011 in the INSERM unit U613 located in the Medical Center of the University of Bretagne Occidentale in Brest (France).
This postdoctoral position is opened in the lab of Dr. Olivier Mignen to investigate the molecular and cellular mechanisms underlying calcium signaling in mammalian cells and its implication in Cystic fibrosis.
Our laboratory is mainly interested in understanding the molecular mechanisms underlying calcium entries in non excitable cells and their roles in health and disease. Calcium entry is essential for many cellular functions including gene expression, secretion, cell motility and cell proliferation and differentiation. We are investigating the molecular components and the control mechanisms of store dependent and store independent calcium entries.
The main objective of the project is to characterize in airway epithelial cells the calcium signaling pathways involved in ion secretion and the potential beneficial roles of their stimulation to counteract the defect of chloride secretion observed in cystic fibrosis. The postdoctoral scientist will also be involved in studies designed to identify protein partners of calcium channels involved in calcium entry and pharmacological modulators of these entries. The knowledge derived from our research may ultimately lead to design novel pharmacological agents to treat Cystic fibrosis. Our project combines different experimental approaches including live-cell imaging, biochemistry, molecular biology and electrophysiology.
Extremely motivated Ph.D.s (maximum of 4 years postdoctoral experience) with a strong background in molecular and cell biology are encouraged to apply. Candidates with demonstrated records in studying calcium signaling will be preferred. Experiences in electrophysiology would be an asset but is not required. The candidate should have proven skills in Western blotting, immunoprecipitation, real time PCR, immunofluorescence, immunohistochemistry, cell culture techniques and in vitro transfection. Additional preferred skills include live cell confocal microscopy and proteomics. Knowledge of the physiology of fluid-secreting epithelia will also be appreciated. The applicant must be enthusiastic with communication skills (English and/or French) in order to be able to join a young starting team located in an excellent environment of research with various state-of-the-art core facilities. The applicant will collaborate with the other members of the unit and must show a high motivation interdisciplinary work. The applicant must have done its PhD outside Britany and defended his thesis less than 4 years ago.
Salary ~ 2000€/month.
Contact Person:
Olivier Mignen
INSERM U613 – IFR148 ScInBioS
Faculté de Médecine et des Sciences de la Santé
22 avenue Camille Desmoulins
F-29200 BREST -FRANCE
tel.: + 33 (0)2 98 01 67 05
fax. : + 33 (0)2 98 01 82 29
e-mail: olivier.mignen@univ-brest.fr
visit our webpage: http://www.genetic-brest.fr/

or

Aurélie Vandebrouck
INSERM U613 – IFR148 ScInBioS
Faculté de Médecine et des Sciences de la Santé
22 avenue Camille Desmoulins
F-29200 BREST -FRANCE
tel.: + 33 (0)2 98 01 81 98
fax : + 33 (0) 2 98 01 82 29
e-mail : aurelie.vandebrouck@univ-brest.fr

Filed Under: Arts & Administration, Doctorate Degree, Grants and Fellowships, Information Technology, Medical Science, Physical Science, Post Doctoral Tags: , , , , , , , , ,

PhD Studentship, Synthetic and Structure-Activity Studies on Hemokinin and Analogues, University of Reading, UK

/ August 22, 2010 Leave a Comment

The peptide under initial investigation is hemokinin (HK1), a decapeptide member of the tachykinin family of peptides identified in the mouse with the sequence SRTRQFYGLM-NH2. The equivalent human peptides are termed “endokinins” and differ in a number of subtle ways from hemokinin. The biology of the peptides is not well understood, although it is believed they play an important part in the regulation of the circulatory system. The approach will be twofold involving both organic synthesis and molecular biology. (i) Synthesis of hemokinin analogues will be carried out in proof of concept studies using a novel general ligation strategy developed in the Harwood group that does away with the need for a cysteine residue at the N-terminus, and permits Fmoc protection for generating the C–terminus thioester. (ii) Binding to mouse tachykinin receptors will be studind using radiolabelled HK1 analogues to establish structure activity profiles and identify agonists/antagonists. The analogues will also be studied for their role in platelet function – specifically secretion, integrin affinity modulation and aggregation, and through studying the cell signalling generated by these and the cell lines, develop an understanding of which specific receptors are of importance for the responses observed. These studies mesh with current expertise and interests with the Bicknell and Gibbins groups and might be further extended to endokinin analogues. Applications forms are available from Mrs. Judy Butler, Postgraduate Secretary, Chemistry Department, University of Reading, Whiteknights, Reading, Berks, RG6 6AD, Telephone Number: 01183786591 or by email j.m.butler@reading.ac.uk. Application Deadline October2010 Read more: http://scholarship-positions.com/phd-studentshipsynthetic-and-structure-activity-studies-on-hemokinin-and-analoguesuniversity-of-reading-uk/2010/08/10/?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+ScholarshipPositions+%28International+Scholarships+and+Financial+Aid+Positions%29&utm_content=Yahoo%21+Mail#ixzz0x8foh5VQ

Filed Under: Doctorate Degree, Physical Science, Post Doctoral Tags: , , , , , , , , , , ,

PhD Research Fellowship in Evolutionary Biology for International Students, Norway

/ August 22, 2010 Leave a Comment

The PhD fellow will be part of a team working on the project “Tracking signatures of adaptive diversification during postglacial colonization in threespine stickleback”. The project is funded by the Research Council of Norway.The overall aims of the project are to detect genomic regions and phenotypic traits under selection when sticklebacks invade fresh waters. To do this we will use a set of genetic methods, including SNP-genotyping and large-scale sequencing. Sticklebacks will be sampled in the field, based on prior information on phenotype distributions. Based on phenotypic and genotypic data the candidate will, depending on prior competence, investigate this adaptation process either using molecular genetic approaches or more statistically based methods. The PhD-candidate will work with supervisors at the CEES (L.A. Vøllestad, T.F. Hansen, K.S. Jakobsen, K. Østbye) and international collaborators (F. Volckaert, A. Nolte).

Requirements:

Applicants must hold a MSc-degree (or equivalent) and have experience in evolutionary biology, molecular biology, molecular genetics, population genetics or quantitative genetics – preferentially with solid experience in several of these field. Good analytical skills are necessary.

For this position, we seek a highly motivated, enthusiastic person with the ambition to gain insight and publish papers in leading, international journals. The successful candidate must be prepared to spend some periods abroad for training and cooperation.

The purpose of the fellowship is research training leading to the successful completion of a PhD degree.

The fellowship requires admission to the research training programme at the Faculty of Mathematics and Natural Sciences. An approved plan for the research training, including a  project outline, must be submitteed no later than two months after taking up the position, and the admission must be approved within three months

The application must  include:

  • a cover letter including a statement of interest, summarizing the applicant’s scientific work and interests and describing how she/he fits the requirements for the position
  • a CV including a list of published and unpublished works
  • transcripts of records, copies of certificates and grades from bachelor and master level
  • two letters from reference persons or names and addresses of two reference persons
  • copies of relevant published papers

Applicants may be called in for an interview.

Foreign applicants are advised to attach an explanation of their University’s grading system. Please remember that all documents should be in English or a Scandinavian language.

Closing date for applications: 20 August, 2010

Filed Under: Doctorate Degree, Masters Degree, Physical Science Tags: , , , , , , , , , , ,
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