Chemical | Scholarship for Nigerians and Africans - Part 13

Postdoctoral Research Assistant in Molecular Neuroscience/Cell Biology, UK

A postdoctoral position is available in the laboratory of Dr Jonathan Hanley, to investigate the neuronal cell biological mechanisms of synaptic plasticity, which is thought to underlie learning and memory. Experiments will utilise molecular, biochemical and imaging techniques to study the signaling pathways and protein interactions that regulate AMPA receptor trafficking and/or dendritic spine morphogenesis in cell culture models of synaptic plasticity and/or ischaemia. The position will involve close collaboration with other members of the MRC Centre for Synaptic Plasticity at the University of Bristol.

The post is available on a fixed term basis for 3 years.

PICK1 interacts with a number of important proteins as part of this trafficking process (Hanley, 2008; Rocca et al., 2008), and we have recently found additional proteins that interact directly with AMPARs or PICK1, that are likely to be important in AMPAR trafficking and/or spine morphology (unpublished).
The aim of the project will be to elucidate the role of these proteins in AMPAR trafficking or dendritic spine morphogenesis in cell culture models of synaptic plasticity or ischaemia.
The MRC Centre for Synaptic Plasticity has state-of-the-art imaging facilities to enable a range of live and fixed-cell techniques, using confocal and wide-field microscopy. The project will involve the use of a variety of molecular and biochemical approaches to investigate protein-protein interactions, and to manipulate protein expression in primary neuronal cultures. Imaging will be carried out in neurons expressing shRNA and/or mutant proteins to analyse the dynamics of spine morphogenesis and receptor trafficking when these protein interactions are altered. In addition, collaborations with electrophysiologists in the MRC Centre will provide important information about the function of these pathways in synaptic transmission.
This work will provide important new information about the mechanisms that underlie physiological and pathological synaptic processes. The successful applicant will join an active and dynamic team and benefit from complementary interests and technical expertise in molecular and cellular neuroscience.
Application Deadline 15 September 2010
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Postdoctoral Research Assistant in Volcano Fluid Dynamics, UK

The Department of Earth Sciences at the University of Bristol (UK) has an opening for a postdoctoral researcher in volcano fluid dynamics, as part of a three-year multidisciplinary research project investigating gas-melt flow regimes in volcanic conduits and their characteristic acoustic signals, in conjunction with the Department of Chemical and Environmental Engineering at the University of Nottingham. One year will be spent at the University of Nottingham to conduct laboratory experiments.

We are looking for a motivated scientist with experience in fluid dynamics (preferably both experimental and theoretical research) and a PhD in engineering, physical volcanology, or applied mathematics. You will carry out and interpret large-scale laboratory experiments to understand gas-liquid flow regimes in conduits and how these relate to eruption style and acoustic signals measured at volcanoes. You will collect and analyse laboratory data, develop physical models to interpret the data, and compare the results to infrasound recordings from volcanoes.

Role holders at this level will have very extensive experience of research leadership and related management/administration. They will enjoy a wide recognition for their expertise within the academic community internationally (as evidenced by conference invitations, journal editorships, office holding in specialist groupings, associations with appropriate Research Councils etc.). They will have made recognised and significant contributions to the developing knowledge and understanding of their research area. They will already have responsibilities for the creation, initiation, development and overall management of significant research programmes. They will ‘profess’ their discipline within the Department, as appropriate and consonant with the terms of their funding. They may also carry significant leadership roles within the Faculty or University.

Application Deadline 27 Aug 2010
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Postdoctoral Research Assistant in Electron Microbeam Laboratory, UK

The Department of Earth Sciences at the University of Bristol (UK) has an opening for a postdoctoral Research Assistant working in the electron microbeam laboratories. There is funding available for 12 months for a part-time (80%) appointment.

We are seeking an enthusiastic candidate with substantial experience working with both SEM and EPMA equipment. You will have a PhD or equivalent in a related subject. You will oversee operation of the equipment and supervise users from a variety of backgrounds. You will undertake two pilot research projects in preparation of grant applications. The role will also involve analysis of data collected over the past several years, and working the data into a manuscript(s) for publication.
The Department of Earth Sciences thrives on a research-intensive environment, characterised by individuals and groups of international standing; working collectively or individually on earth science problems of global concern. The department is loosely divided into five research groups, united by a common research goal or common equipment, but with an emphasis on interdisciplinary collaboration between them. A brief summary of these groups and their research goals and membership is given below.

The Deep Earth research group uses high-pressure high-temperature experimental petrology and seismology to study the chemical differentiation of the earth and dynamics of the crust and mantle: Profs: Kendall, Blundy FRS, Helffrich, Walter. Drs: Kohn, Montgomery, Schumacher, Wookey, Rychert. Dohmen, Caricchi, Saunders (+6 PDRA, 7 PG).
The Geochemistry group uses isotopic and elemental abundances to quantify processes from planetary evolution, through melt generation and differentiation, to climate change and surface chemical cycles: Profs: Sherman, Elliott, Vance. Drs: Coath (+9 PDRA, 19 PG).
The Palaeobiology and Biodiversity group, covers a breadth of time scales and organismal groups to understand biological evolution on Earth. Research methodology combines traditional observational studies of fossils with pioneering developments in: numerical and phylogenetic analysis, biomechanical modelling, X-ray tomography and molecular biological techniques, placing the group at the forefront of paleobiological investigations. Profs: Benton. Drs: Anderson, Braddy, Donoghue, Loeffler, Rayfield, Ruta, Rücklin, Schmidt, Hendy. (+3 PDRA, 14 PG)
The Climate and Environmental Change group includes experts in Earth system science, biogeochemistry, biosphere-atmosphere interactions, the carbon cycle, climate change and studies large-scale Earth system processes and interactions, and the linkages among environmental change, human activities and policy. Drs: Cornell, P. Foster, Hendy, Hornibrook, Knorr, Scholze, Siddall, Whitaker. Ms. House (+4 PDRA, 4 PG).

Application Deadline 1September2010