This project aims to address fundamental questions concerning the effects of drug related toxicity on mitochondrial function by making use of the nematode C. elegans as a model system. The main questions that will be addressed concern the quantative analysis of drug-induced ROS production and oxidative damage in relation to mitochondrial function, assembly and ageing. The work is embedded in the theme ‘Quantitative systems analysis of biological stress response’ and will be reinforced by the start of a new PI, after a post-doc at Stanford, who will use C. elegans to study mechanisms of ageing.
Requirements

* A master degree in Biomedical Sciences, Biochemistry, Cell biology, or Molecular biology (or equivalent)
* Experience with molecular biological techniques, protein techniques
* Interest in quantitative analysis
* Experience with C. elegans is an advantage
* The ability to work in a team as well as independently
Scholarship Application Deadline: 1 February 2011
Further Scholarship Information and Application