Bacterial pathogen subversion of the mammalian actin cytoskeleton
Applications are invited for a PhD studentship, supervised by Prof. Vassilis Koronakis, to research mechanisms underlying bacterial pathogen subversion of the mammalian cytoskeleton. Actin polymerisation is mediated by a complex signalling network requiring small G-protein activation that target N-WASP and the SCAR/WAVE complex to initiate Arp2/3-dependent actin nucleation. The detailed processes by which cellular signal transduction cascades lead to the formation of discrete actin structures remain unresolved. These signalling pathways are hijacked by pathogens like Salmonella and E.coli to promote colonisation, survival and dissemination, deploying virulence (effector) proteins to manipulate host actin dynamics.
The student will dissect key eukaryotic signalling networks targeted by these bacterial pathogens using a multidisciplinary approach involving the culture and infection of mammalian cells, cell biology, fluorescence microscopy, protein biochemistry and molecular genetics. Detailed characterisation of the mechanisms underlying actin polymerisation will not only reveal the molecular basis of disease, but also illuminate fundamental processes in cell biology.
Experience and/or Masters degree is desirable.
How to apply:
Applicants should hold or be about to achieve a First or Upper-Second (2.i) class degree in a relevant subject. Experience and/or Masters degree is desirable.
Shortlisted candidates will be required to formally apply through completion of a Graduate and Scholarship Application Form (GRADSAF) before attending interview.
Applications from ineligible candidates will not be considered.
Application Deadline: 28 February 2011.
