molecular biology techniques | Scholarship for Nigerians and Africans

University of Central Lancashire International PhD Scholarship in School of Pharmacy & Biomedical Sciences, UK

Applications are invited for a full-time scholarship available in the School of Pharmacy & Biomedical Sciences. The scholarship is tenable for up to 3 years for a PhD (via MPhil route) [subject to satisfactory progress] and is open to international applicants only. UK/EU applicants are not eligible to apply. The scholarship will provide £15000 towards the cost of the International tuition fee over 3 years. A wide range of human diseases (e.g. cancer, diabetes, atherosclerosis) are accompanied by enhanced intracellular lipid droplet formation. In recent years, sterol regulatory element binding proteins (SREBPs) have been shown to regulate the expression of key lipid synthesis genes including those encoding fatty acid synthase, acetyl-CoA carboxylase and ?9 desaturase. It is proposed that SREBPs function as allostatic nodes which contribute to cellular lipid quality control processes. Consequently, their activity is closely controlled through a variety of upstream (mTOR/Akt pathways) and downstream (metabolic products e.g. saturated fatty acids, cholesterol) effectors. The project will utilise a number of species of yeast, including Schizosaccharomyces pombe, Saccharomyces cerevisie and Lipomyces starykei, to determine the underlying transcriptional control of acyl lipid metabolism and lipid droplet formation. Using a variety of stimuli, we will investigate which transcription factors are involved in the promotion of acyl lipid metabolism and desaturation. This will involve the use of a number of molecular biology techniques including Northern blot and microarray analysis, to identify important regulatory proteins, and chromatin immunoprecipitation (CHiP), to determine regulatory elements within target genes. Furthermore, the genetic manipulation of yeast is relatively facile providing the opportunity to decipher the functional components of these regulatory pathways and identify future drug targets.

Scholarship Application Deadline: 13 May 2011

Further Scholarship Information and Application

PhD Studentship in the Department of Haematology at University of Cambridge, UK

Functional characterization of novel regulators of haematopoiesis and platelet function in Danio rerio A PhD position is available jointly supervised by Dr Ana Cvejic and Professor Willem H Ouwehand who have an international track record in megakaryocyte and platelet biology and genomics. Genome-wide association studies (GWAS) provide a new and powerful approach to identify novel regulators of haematopoiesis and platelet function. In a next step we want to explore the mechanisms by which common sequence variation exerts its effect on haematopoiesis. This PhD project will initially apply high-throughput screening methods in Danio rerio to determine the function of novel genes, identified by GWAS, in haematopoiesis. Further studies will focus on novel genes encoding proteins that are important regulators of transcription. The successful applicant will be trained in performing experiments with Danio rerio applying a variety of molecular biology and next generation sequencing techniques, state-of-the-art imaging systems, in situ hybridisation and immunohistochemistry and will mainly work in the Zebrafish genetics group of Dr Derek Stemple at the Wellcome Trust Sanger Institute.
We are seeking applications from ambitious and highly motivated individuals looking to work in an interdisciplinary environment with education, experience or interest in haematopoiesis. Applicants should have a first or upper second-class degree in biology, biochemistry or related subjects. Familiarity with molecular biology techniques would be advantageous. This 4-year studentship will cover University composition fees, College fees and a £16,500 stipend for UK/EEA applicants.

Scholarship Application Deadline: 15 April 2011

Further Scholarship Information and Application

Senior Research Fellowship, School of Biosciences and Technology, VIT University, India

Applications are invited for the Post of Senior Research Fellow (SRF) for the Council of Scientific and Industrial Research (CSIR), Govt. of India Funded project entitled, “Biochemical and Molecular investigation of Plant Dyes” in School of Bio Sciences and Technology (SBST), VIT University, Vellore – 632 014.

Number of positions: One

Qualification: M.Sc. (Biotechnology) with one or two years experience. Knowledge on chromatographic and Molecular Biology techniques is mandatory and NET qualified candidate will be preferred.

Duration of the project : 3 years

Fellowship : Rs.16000/- per month.

Scholarship Application Deadline: 3 March 2011

Further Scholarship Information and Application